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Safety Data Sheet (SDS) Purified Anti-mouse CD202b Tie-2 CD202 Antibody     Product Data Sheet (PDF)    
Purified Anti-mouse CD202b (Tie-2, CD202) Antibody
1220005 50 µg $80.00       
1220010 200 µg $180.00       
Clone: TEK4
Isotype: Rat IgG1, κ
Reactivity: Mouse
Formulation: Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application:

FC - Quality tested
IF - Reported in the literature

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References:

1. Fathers KE, et al. 2005. Am. J. Pathol. 167:1753.
2. Sanchez-Martin L, et al. 2011. Blood 117:88. PubMed

C57BL/6 bone marrow myeloid cells

C57BL/6 bone marrow myeloid cells stained with purified TEK4, followed by biotinylated anti-rat IgG and Sav-PE



Description:

CD202b, also known as Tie-2 or TEK, is a 145 kD type I transmembrane protein. It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator of CD202b to promote, maintain, and stabilize mature vessels and to maintain HSCs in the quiescent state. Ang-2 is another ligand of CD202b, which is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie-2 also binds to Ang-4.

Other Names: Tie-2, TEK
Structure: The receptor tyrosine kinase (RTK) family
Distribution: Endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes
Antigen References:

1. Fathers KE, et al. 2005. Am. J. Pathol. 167:1753.
2. Yano M, et al. 1997. Blood 89:431726.
3. Kolatsi-Joannou M, et al. 2001. Dev. Dyn. 222:1206.