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Safety Data Sheet (SDS) FITC Anti-mouse CD22 Antibody     Product Data Sheet (PDF)    
FITC Anti-mouse CD22 Antibody
1230525 50 µg $95.00       
1230530 500 µg $295.00       
Clone: OX-97
Isotype: Rat IgG1, κ
Reactivity: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl. It is recommended that the reagent be titrated for optimal performance for each application.

C57BL/6 splenocytes stained with OX-97

C57BL/6 splenocytes stained with OX-97 FITC



Description:

CD22 is a member of the sialoadhesion family.CD22 is expressed on the surface of a subpopulation of mature B lymphocytes and may modulate signaling through the B cell antigen receptor. The OX-97 monoclonal antibody recognizes the second domain of the CD22.

Other Names: Lyb-8, BL-CAM
Structure: 130-150 kd type 1 transmembrane glycoprotein. It is a member of the Siglec family and Ig superfamily.
Distribution: CD22 is expressed in the cytoplasm of pro-B and pre-B cells, and on the surface of mature B and activated B cells, but not on plasma cells.
Function: B cell signaling and adhesion.
Interaction: Associates with SHP-1, Syk, Lck, Lyn and others.
Antigen References:

1. Symington FW et al. 1982. Immunogenetics 16:381
2. Erickson LD et al. 1996. Int Immunol 8:1121
3. Doody GM et al. 1995. Science 269:242