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Safety Data Sheet (SDS) Alexa Fluor 647 Anti-rat CD134 OX-40 Antibody     Product Data Sheet (PDF)    
Alexa Fluor® 647 Anti-rat CD134 (OX-40) Antibody
1622550 100 µg $220.00       
Clone: OX-40
Isotype: Mouse IgG2b, κ
Reactivity: Rat
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Application References:

Al-Shamkhani A, et al. 1996. Eur J. Immunol. 26:1695

ConA-stimulated LOU rat splenocytes stained

ConA-stimulated LOU rat splenocytes stained with OX-40 Alexa Fluor® 647 and 1F4 (CD3) FITC



Description:

CD134 (OX-40 receptor)is a 50 kd type I membrane protein, expressed on activated T cells.It binds to the OX-40 ligand (CD252) to provide a co-stimulatory signal that is independent of CD28.It is reported to block binding of CD134 and CD252.

Other Names: OX-40 receptor , TNFRSF4, ACT35, OX40
Structure: 50 kd type I integral membrane protein, member of NGFR/TNFR superfamily.
Distribution: Expressed mainly on activated CD4+ and CD8+ T cells.
Function: Binds to the OX-40 ligand (CD252) to provide a co-stimulatory signal for T cells.
Ligand Receptor: CD252 (OX-40 ligand)
Antigen References:

1. Al-Shamkhani A et al. 1996. Eur. J. Immunol. 26:1695
2. Paterson DJ et al. 1987. Mol Immunol 24:1281


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