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Safety Data Sheet (SDS) Purified Anti-mouse DLL1 Antibody     Product Data Sheet (PDF)    
Purified Anti-mouse DLL1 Antibody
1241505 50 µg $100.00       
Clone: HMD1-3
Isotype: Armenian Hamster IgG
Reactivity: Mouse
Immunogen: CHO cells expressing murine Dll 1
Formulation: This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 50% glycerol.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: Store undiluted between 2°C and 8°C. Do not freeze.
Application:

FC - Quality tested
IHC - Reported in the literature

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References:

1. Moriyama Y, et al. 2008. Int. Immunol. 20:763.

FD1/CHO (mouse DLL1 transfected cel

FD1/CHO (mouse DLL1 transfected cel l line) stained with purified HMD1-3, followed by anti-Armenian hamster IgG PE



Description:

The Notch receptors and their ligands are highly conserved from invertebrates to mammals. The Delta-like 1 (DLL1) is one of the four or five Notch ligands identified. The binding to Notch receptor results in the proteolysis of Notch and movement of intracellular portion of Notch into the nucleus.This translocation triggers a series of signaling process. Delta-like 1 is reported to be essential for the maintenance of marginal zone B cells in normal mice, and engagement of Notch 1 by DLL1 promotes differentiation of B lymphocytes to antibody-secreting cells.

Other Names: Dll 1, Dll-1
Structure: A single pass transmembrane protein consisting of a large extracellular N-terminal which includes the DSL domain, followed by a tandem array of EGF-like repeats (ELRs). After a single transmembrane domain (TM) is a novel intracellular domain.
Distribution: B cells
Function: The Notch receptors and their ligands are highly conserved signaling molecules throughout development. They regulate cell fate decision for various cell development, including myogenesis, neurogenesis, and lymphocyte development.
Ligand Receptor: Notch receptors
Antigen References:

1. Ehebauer MT, et al. 2006. Biochem. J. 392:13.
2. Shimizu K, et al. 2000. Mol. Cell. Biology 20:18.
3. Parks AL, et al.2006. Genetics 174:1947.
4. Santos MA, et al. 2007. P. Natl. Acad. Sci. USA 104:15454.