Sony Biotechnology Inc. Sony Biotechnology Inc.cart
About Us Products What's New Library News Calendar Contact Us Place Order
Safety Data Sheet (SDS) PE Anti-mouse DLL1 Antibody     Product Data Sheet (PDF)    
PE Anti-mouse DLL1 Antibody
1241535 50 µg $150.00       
Clone: HMD1-3
Isotype: Armenian Hamster IgG
Reactivity: Mouse
Immunogen: CHO cells expressing murine Dll 1
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg/test for FC. It is recommended that the reagent be titrated for optimal performance for each application.

Application References:

1. Moriyama Y, et al. 2008. Int. Immunol. 20:763.

LPS-stimulated BALB/c peritoneal macrophages (Day

LPS-stimulated BALB/c peritoneal macrophages (Day 2) stained with HMD1-3 PE



Description:

The Notch receptors and their ligands are highly conserved from invertebrates to mammals. The Delta-like 1 (DLL1) is one of the four or five Notch ligands identified. The binding to Notch receptor results in the proteolysis of Notch and movement of intracellular portion of Notch into the nucleus.This translocation triggers a series of signaling process. Delta-like 1 is reported to be essential for the maintenance of marginal zone B cells in normal mice, and engagement of Notch 1 by DLL1 promotes differentiation of B lymphocytes to antibody-secreting cells.

Other Names: Dll 1, Dll-1
Structure: A single pass transmembrane protein consisting of a large extracellular N-terminal which includes the DSL domain, followed by a tandem array of EGF-like repeats (ELRs). After a single transmembrane domain (TM) is a novel intracellular domain.
Distribution: B cells
Function: The Notch receptors and their ligands are highly conserved signaling molecules throughout development. They regulate cell fate decision for various cell development, including myogenesis, neurogenesis, and lymphocyte development.
Ligand Receptor: Notch receptors
Antigen References:

1. Ehebauer MT, et al. 2006. Biochem. J. 392:13.
2. Shimizu K, et al. 2000. Mol. Cell. Biology 20:18.
3. Parks AL, et al.2006. Genetics 174:1947.
4. Santos MA, et al. 2007. P. Natl. Acad. Sci. USA 104:15454.