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Safety Data Sheet (SDS) Purified Anti-mouse IL-21R Antibody     Product Data Sheet (PDF)    
Purified Anti-mouse IL-21R Antibody
1259510 500 µg $295.00       
Clone: 4A9
Isotype: Rat IgG2a, κ
Reactivity: Mouse
Immunogen: Rat YB2/0 hybridoma transfectant cell line expressing truncated IL-21R
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application:

FC - Quality tested
IP - Reported in the literature

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References:

1. Jin H, et al. 2004. J. Immunol. 173:657. (FC)
2. Jin H and Malek T. 2006. J. Leukocyte Biol. 80:1416. (FC IP)



Description:

The IL-21R is a member of the cytokine receptor family that closely resembles IL-2R beta and IL-4R alpha. IL-21R is expressed by all mature lymphocytes and up-regulated after B and/or T cell activation, with the highest expression by activated B cells. A functional IL-21R consists of the IL-21R subunit and the commone gamma-chaiin. Upon binding to IL-21, it activates Jak-1, Jak-3, STAT1, STAT3 and STAT 5 transduction pathway.

Other Names: IL-21 Receptor
Structure: A member of the class 1 cytokine receptor family. Show significant sequence and structural homology with the IL-4R alpha chain.
Distribution: Express on all mature lymphocytes including B cells, T cells, and NK cells. Reported to be up-regulated upon activation and highest expression on follicular B cells.
Ligand Receptor: IL-21
Antigen References:

1.Mehta DS, et al. 2004. Immu Reviews 202:84