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Safety Data Sheet (SDS) PE Anti-mouse CD132 Common Gamma Chain Antibody     Product Data Sheet (PDF)    
PE Anti-mouse CD132 (common γ Chain) Antibody
1261525 50 µg $115.00       
1261530 200 µg $295.00       
Clone: TUGm2
Isotype: Rat IgG2b, κ
Reactivity: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume It is recommended that the reagent be titrated for optimal performance for each application.

Application References:

1. Kondo M, et al. 1993. Science 262:1874 (Block)
2. Kondo M, et al. 1994. Science 263:1453
3. Kimura Y, et al. 1995. Int Immunol. 7:115 (Block)
4. Veerman KM, et al. 2012. J. Immunol. 188:1638. PubMed.
5. Hennion-Tscheltzoff O, et al. 2013. Blood. 121:4684. PubMed

C57BL/6 splenocytes stained with TUGm2

C57BL/6 splenocytes stained with TUGm2 PE



Description:

CD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, and is also known as common γ chain (γc) or IL-2 receptor γ subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Ligand binding induces tyrosine phosphorylation and initiates signaling through a JAK/STAT pathway. CD132 mutation results in X-linked severe combined immune deficiency (XSCID).

Other Names: Common γ chain, γc, IL-2 receptor γ subunit
Structure: Type I transmembrane glycoprotein, Ig superfamily 64-70 kD
Distribution: T cells, B cells, NK, monocytes, granulocytes
Function: Signaling
Ligand Receptor: Component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21
Antigen References:

1. Itano M, et al. 1996. Tohoku J. Exp. Med. 178:389
2. Zola H, et al. eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication
3. Nakarai T, et al. 1994. J. Exp. Med. 180:241
4. Kawahara A, et al. 1995. Proc. Natl. Acad. Sci. USA. 92:8724
5. Habib T, et al. 2002. Biochemistry. 41:8725
6. Matthews DJ, et al. 1995. Blood 85:38