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Safety Data Sheet (SDS) PE Anti-mouse MAIR-V Antibody     Product Data Sheet (PDF)    
PE Anti-mouse MAIR-V Antibody
1263520 100 µg $260.00       
Clone: TX70
Isotype: Rat IgG2a, κ
Reactivity: Mouse
Immunogen: MAIR-V transfectant (BW5147)
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.015 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

MAIR-V transfected cells stained with

MAIR-V transfected cells stained with TX70-PE



Description:

The myeloid-associated immunoglobulin-like receptor family (CD300) consists of nine activating or inhibitory cell surface receptors preferentially expressed on myloid cells and are encoded by the genes in a small cluster on mouse chromosome 11. MAIR-V is one of the family members. MAIR-V regulates the activation of myeloid cells. It has been reported that cross-linking MAIR-V with anti-MAIR-V monoclonal antibody induced cell death in peritoneal macrophages as well as transfectants. Data suggested that MAIR-V is one of the inhibitory receptors in the family. The functional of characteristics of this receptor are still not clear. Monoclonal antibody TX70 recognized both MAIR-Va and MAIR-Vb.

Other Names: CD300LF, CD300f, CMRF35-like molecule 1, Myeloid-associated immunoglobulin-like receptor 5
Structure: MAIR-V belongs to the myeloid-associated immunoglobulin-like receptor family. It has two isoforms, MAIR-Va and MAIR-Vb. MAIR-V contains a consensus immunoreceptor tyrosine-based switching motif (ITSM) as well as two ITIMs in the cytoplasmic tail.
Distribution: It was reported that CD300LF is expressed on myeloid cells, including macrophages, neutrohils, DCs, and bone marrow derived mast cells. The expression profile of MAIR-V is still incompletely understood.
Antigen References:

1. Can Ismail, et al. 2008. Hybridoma. 27 (1):59-61
2. Can Ismail, et al. 2008. J. Immunol. Sep; 180:207-213
3. Totsumoto K, et al. 2003. J. Exp. Med. 198:223-233