Sony Biotechnology Inc. Sony Biotechnology Inc.cart
About Us Products What's New Library News Calendar Contact Us Place Order
Safety Data Sheet (SDS) PE Anti-mouse CD267 TACI Antibody     Product Data Sheet (PDF)    
PE Anti-mouse CD267 (TACI) Antibody
1267015 50 µg $85.00       
1267020 200 µg $220.00       
Clone: 8F10
Isotype: Rat IgG2a, κ
Reactivity: Mouse
Immunogen: Rat RBL transfected cell line
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per 106 cells in 100 µl. It is recommended that the reagent be titrated for optimal performance for each application.

Application References:

1. Siegel RM, et al. 2001. Nat. Immunol. 2:577.
2. Von Bulow GU, et al. 1997. Science 278:138.
3. Yan M, et al. 2001. Nat. Immunol. 2:638.
4. Diaz-de-Durana Y, et al. 2006. Blood 107:594.
5. Moir S, et al. 2012. Blood. 120:4850. PubMed.

C57BL/6 splenocytes stained with 8F10

C57BL/6 splenocytes stained with 8F10 PE and RA3-6B2 APC



Description:

Transmembrane Activator and CAML Interactor (TACI) is a tumor necrosis factor receptor superfamily (TNFSF) member. It is a type III transmembrane protein sharing a high degree of homology with B cell maturation antigen (BCMA) among TNFSF members. It binds to the ligands BAFF (BLyS) and APRIL. CD267 appears to be particularly important for the regulation of B cell survival and maturation in the spleen. It is a major mediator of BAFF-dependent costimulatory responses in peripheral B cells. Signaling through TACI may serve to down-regulate B cell activity as well. The actual role for TACI in the mouse has still not been fully determined.

Other Names: TACI
Structure: TACI/CD267 is a type III transmembrane protein belonging to TNF receptor superfamily (TNFSF). Among TNFSF members, TACI shares a high degree of homology with B cell maturation antigen (BCMA). It binds to the ligands BAFF (BLyS) and APRIL.
Distribution: CD267 is expressed predominantly by splenic transitional type 2 and marginal zone B cells, as well as activated B cells. But it is notably absent from germinal center B cells.
Function: CD267 appears to be particularly important for the regulation of B cell survival and maturation in the spleen. It is a major mediator of BAFF-dependent costimulatory responses in peripheral B cells. Signaling through TACI may serve to down-regulate B cell activity.
Ligand Receptor: BAFF (Blys/TALL-1/THANK) and APRIL
Antigen References:

1. Ng LG, et al. 2004. J. Immunology. 173:807.