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Safety Data Sheet (SDS) PE Anti-mouse DcTRAIL-R2 Antibody     Product Data Sheet (PDF)    
PE Anti-mouse DcTRAIL-R2 Antibody
1268515 25 µg $105.00       
Clone: mDcR2-1
Isotype: Armenian Hamster IgG
Reactivity: Mouse
Immunogen: mDcTRAIL-R2-Fc
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Mouse macrophage cell line RAW

Mouse macrophage cell line RAW stained with mDcR2-1 PE



Description: Mouse Decoy Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Receptor 2 (mDcTRAIL-R2) is highly homologous to mDcTRAIL R1. It is a GPI-anchored mouse TNF receptor super-family member that lacks a cytoplasmic death domain. It is expressed on many cell types, including some tumor cells. It was reported that overexpression of mDcTRAIL-R2 did not induce caspase activation that is characteristic of death receptor signaling. mDcTRAIL-R2 appears to have a negative effect against TRAIL receptors because it lacks an intracellular death domain, and produces a competitive blockage of TRAIL-mediated apoptosis. The role of the DcTRAIL-R2 in apoptosis has not yet been completely clarified.
Other Names: TNFRH2, Tnfrsf22, SOBa, Tnfrsf1al2, mDcTrailr2, tumor necrosis factor receptor superfamily member 22
Structure: GPI-anchored mouse TNF receptor super-family member that lacks a cytoplasmic death domain.
Distribution: Express on many types of cells, including some tumor cells.
Function: Appear to have a negative effect against TRAIL receptors because it lacks an intracellular death domain, and produces a competitive blockage of TRAIL-mediated apoptosis.
Ligand Receptor: TRAIL
Antigen References: 1. Schneider P, et al. 2003. J. Bio. Chem. 278(7):5444
2. Yagyu S, et al. 2008. Clin Cancer Res. 14 (21):7011
3. Ashkenazi A, et al. 1998. Science. 281:1305