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Safety Data Sheet (SDS) PE Anti-mouse DcTRAIL-R1 Antibody     Product Data Sheet (PDF)    
PE Anti-mouse DcTRAIL-R1 Antibody
1269020 100 µg $260.00       
Clone: mDcR1-3
Isotype: Armenian Hamster IgG
Reactivity: Mouse
Immunogen: mDcTRAIL-R1-Fc
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References:

1. Bareiss PM, et al. 2013. Cancer Res. 73:5544. PubMed

Mouse macrophage cell line RAW

Mouse macrophage cell line RAW stained with mDcR1-3 PE



Description:

Mouse Decoy Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Receptor 1 (mDcTRAIL R1) is a GPI-anchored mouse TNF receptor super-family member that lacks a cytoplasmic death domain. It expresses on many cell types, including some tumor cells. mDcTRAIL R1 appears to have a negative effect against TRAIL receptors because it lacks an intracellular death domain, and produces a competitive blockage of TRAIL-mediated apoptosis. The role of the DcR1 in apoptosis has not yet been clarified.

Other Names: TNFRH1, mSOB, Tumor necrosis factor receptor superfamily member 23, Tnfrsf23, Tumor necrosis factor receptor p60 homolog 1, TNF receptor family member SOB, Decoy TRAIL receptor 1, TNF receptor homolog 1
Structure: GPI-anchored mouse TNF receptor super-family member that lacks a cytoplasmic death domain.
Distribution: Express on many types of cells, including some tumor cells.
Function: Appear to have a negative effect against TRAIL receptors because it lacks an intracellular death domain, and produces a competitive blockage of TRAIL-mediated apoptosis. The role of the DcR1 in apoptosis has not yet been clarified.
Ligand Receptor: TRAIL
Antigen References:

1. Yagyu S, et al. 2008. Clin Cancer Res. 14 (21):7011
2. Ashkenazi A, et al. 1998. Science 281:1305