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Safety Data Sheet (SDS) PE Anti-mouse Lymphotoxin Beta Receptor LTbetaR Antibody     Product Data Sheet (PDF)    
PE Anti-mouse Lymphotoxin Beta Receptor (LTβR) Antibody
1272015 25 µg $105.00       
Clone: 5G11
Isotype: Rat IgG2a, κ
Reactivity: Mouse
Immunogen: E.coli expressed extracellular domain of mouse lymphotoxin beta receptor
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

C57BL/6 bone marrow cells stained

C57BL/6 bone marrow cells stained with 5G11 PE (Upper panel) or rat IgG2a isotype control PE (Lower panel) and Ly-6G/Ly-6C FITC





Description:

LTβR is a type I transmembrane glycoprotein and member of the TNF receptor superfamily. It is a 61 KDa receptor for the mouse LTα1β2 and LIGHT. Northern blot analysis of tissues from adult mice showed that expression levels of LTβR mRNA were strong in lung, liver, and kidney, moderate in heart and testes, but weak in brain, thymus, spleen, and lymph nodes. It was reported that LTβR is expressed on stromal cells, monocytes, and certain embryonic epithelial layers. LTβR is involved in peripheral lymphoid tissue organogenesis and function. The LTα/LTβR receptor system may also have some function in early embryogenesis.

Other Names: LTbR, TNFRIII, TNF receptor-related protein (TNFRrp)
Distribution: Expressed on stromal cells, monocytes, and certain embryonic epithelial layers.
Function: LTβR is involved in peripheral lymphoid tissue organogenesis and function. The LTα/LTβR receptor system may also have some function in early embryogenesis.
Ligand Receptor: LTα1β2 and LIGHT
Antigen References:

1. Force WR, et al. 1995. J. Immunol. 155:5280
2. Tamada K, et al. 2000. J. Immunol. 164:4105
3. Browing JL, et al. 1997. J. Immunol. 159:3288
4. Futterer A, et al. 1998. Immunity 9:59
5. Nakamura T, et al. 1995. Genomics 30:312
6. Crowe P, et al. 1996. Science 264:707
7. Dejardin E, et al. Immunity 2002. 17(4):525