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Safety Data Sheet (SDS) Purified Anti-IRF4 Antibody     Product Data Sheet (PDF)    
Purified Anti-IRF4 Antibody
3832010 100 µg $220.00       
Clone: IRF4.3E4
Isotype: Rat IgG1, κ
Reactivity: Mouse, Human
Immunogen: GST fusion protein containing C-terminal of murine IRF4
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application:

WB - Quality tested
ICFC - Reported in the literature

Recommended Usage:

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 10 µg/ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application References:

1. Zheng Y, et al. 2009. Nature 458:351
2. Yin SY, et al. 2011. Exp Cell Res. 317:2210. PubMed

Western blot analysis of Daudi

Western blot analysis of Daudi (lane 1) , Raji(lane 2) and A20 (lane 3) cells using IRF4 antibody (clone IRF4.3E4). β-actin antibody (poly6221) was used as loading control.



Description:

The IRF family consists of at least nine members. IRF4 and IRF8 are highly homologous to each other and also redundant in function. IRF4 is critical for Th2 and Th17 development. Together with TRF8, it plays an essential role in macrophage and dendritic cell development and function. IRF4 is also reported to be essential for pre-B cell development, receptor editing, germinal center reactor and plasma cell differentiation.

Other Names: Interferon regulatory factor 4
Structure: Molecular weight is approximately 51 kD.
Distribution: IRF4 is reported to be expressed exclusively in the immune system.
Antigen References:

1. Lu R. 2008. Trends Immunol 29:487.