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Safety Data Sheet (SDS) APC Anti-mouse CD270 HVEM Antibody     Product Data Sheet (PDF)    
APC Anti-mouse CD270 (HVEM) Antibody
1281525 25 µg $110.00       
1281530 100 µg $265.00       
Clone: HMHV-1B18
Isotype: Armenian hamster IgG
Reactivity: Mouse
Immunogen: Mouse HVEM-hIgG1Fc fusion protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
C57BL/6 splenocytes stained with HMHV-1B18

C57BL/6 splenocytes stained with HMHV-1B18 APC



Description:

Herpes Virus Entry Mediator (HVEM, TR2) is a type I transmembrane protein of TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HAS) entry. Binding of HSV viral envelope glycoprotein D to this receptor has been shown to be part of the viral entry mechanism. It is expressed on most cell types, including T cells, B cells, monocytes, neutrophils, and dendritic cells. It is also found in brain, heart, kidney, liver, and other organs. The ligands of HVEM are LIGHT, BTLA, LTα, and CD160. HVEM activates NF-kB through the TNF-related cytokine LIGHT to serve as a costimulatory pathway during T cell activation. HVEM also functions as a ligand for the Ig superfamily members B and T lymphocyte attenuator (BTLA) and CD160 to deliver a coinhibitory signal and limit inflammatory responses initiated by T cells. HVEM plays an important role in regulating lymphocyte activation and homeostasis in immune responses.

Other Names: Herpes virus entry mediator, TR2, tumor necrosis factor receptor like 2, TNFRSF14
Structure: A type I transmembrane protein of TNF-receptor superfamily.
Distribution: It is expressed on most cell types, including T cells, B cells, monocytes, neutrophils, and dendritic cells. It is also found in brain, heart, kidney, liver, and other organs.
Function: Plays an important role in regulating lymphocyte activation and homeostasis in immune responses.
Ligand Receptor: LIGHT, BTLA, LTα, CD160
Antigen References:

1. Fan Z, et al. 2006. Blood 107:1342
2. Granger SW, et al. 2008. Stem Cells. 27:653
3. Kwon BS, et al. 1997. J. Biol. Chem. 272:13471
4. Gonzalez LC, et al. 2005. Proc. Nat. Acad. Sci. U. S. A. 102:1116
5. Montgomery RI, et al. 1996. Cell. 87:427
6. Cheung TC, et al. 2009. Proc. Nat. Acad. Sci. U. S. A. 106:6244
7. Cai G, et al. 2009. Immunol. Rev. 229:244