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Safety Data Sheet (SDS) PE Anti-mouse/human CD351 Fc Alpha/µ Receptor Antibody     Product Data Sheet (PDF)    
PE Anti-mouse/human CD351 (Fc α/µ Receptor) Antibody
1286530 200 µg $320.00       
Clone: TX61
Isotype: Mouse IgG1, κ
Reactivity: Mouse, Human
Immunogen: mFcα/µ receptor transfected Ba/F3 cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Application Notes:

Additional reported (for relevant formats) application include: blocking binding of both IgM and IgA to the mFcα/µ receptor2.

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References:

1. Cho Y, et al. 2006. Biochem. Biophys. Res. Commun. 345:474.
2. Shibuya A, et al. 2006. Springer Semin. Immunopathol. 28:377.
3. Anguetil F, et al. 2015. J Immunol. 194:3664. PubMed

Con-A stimulated C57BL/6 splenocytes (3

Con-A stimulated C57BL/6 splenocytes (3 days) were stained with CD3 APC and CD351 (clone TX-61) PE (top) or mouse IgG1, κ (bottom).





Description:

Fcα/µ receptor (Fcα/µR), CD351, is a type I transmembrane protein with an Ig-like domain in extracellular portion.  It is a novel Fc receptor for IgM and IgA.  Fcα/µ receptor mRNA has been found in thymus, spleen, liver, kidney, intestines, testes, placenta, and T cell leukemia cell lines.  Fcα/µ receptor protein expression is detected on B cells, macrophages, and activated T cells.  Fcα/µ receptor mediates primary B lymphocyte endocytosis of IgM-coated Staphylococcus aureus.   It is involved in the primary stages of the immune response to microbes.

Other Names: Fcα/μ receptor, Fcα/μR
Structure: About 70 kD transmembrane glycoprotein with an Ig-like domain in extracellular portion.
Distribution: B cells, macrophages, and activated T cells.
Function: Mediate primary B lymphocyte endocytosis and involve in the primary stages of the immune response to microbes.
Ligand Receptor: IgA and IgM
Antigen References:

1. Shibuya A, et al. 2000. Nat. Immunol. 1(5):441.
2. Sandor M, et al. 1992. J. Immunol.. 148(8):2363.
3. Cho Y, et al. 2010. Mol. Immunol. 47(4):878.