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Safety Data Sheet (SDS) PE Anti-mouse TCR Vbeta12 Antibody     Product Data Sheet (PDF)    
PE Anti-mouse TCR Vβ12 Antibody
1298515 25 µg $100.00       
1298520 100 µg $215.00       
Clone: MR11-1
Isotype: Mouse IgG1, κ
Reactivity: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.06 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application References:

1. Joshi P, et al. 2006. J Leukoc Biol. 80:1345. (FC)

C57BL/6 mouse lymph node stained

C57BL/6 mouse lymph node stained with TCR Vβ12 (MR11-1) PE and CD3 (145-2C11) APC



Description:

T cell receptor Vβ12 (TCR Vβ12) is a variant of TCR β chain and, along with TCR α chain, forms the TCR heterodimer. In association with the CD3 complex, TCR α/β is responsible for antigen recognition through interaction with MHC-peptide complex to initiate the T cell-mediated immune responses. The MR11-1 antibody reacts with the Vβ12 TCR of mice bearing the b haplotype. It has been reported that Mtv-8 and Mtv-9 cause clonally deletion of Vβ12+ T cells.

Other Names: Vβ12 T-cell receptor, T cell receptor beta 12
Structure: Member of the immunoglobulin superfamily, Vβ12 is a variant of the TCR β chain which associates with the TCR α chain to form the TCR heterodimer
Distribution: subset of TCR αβ+ T cells
Function: Recognition of peptides presented in the MHC molecules, responsible for T cell mediated immune responses