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Safety Data Sheet (SDS) APC Anti-mouse CD155 PVR Antibody     Product Data Sheet (PDF)    
APC Anti-mouse CD155 (PVR) Antibody
1257545 25 µg $110.00       
1257550 100 µg $275.00       
Clone: TX56
Isotype: Rat IgG2a, κ
Reactivity: Mouse
Immunogen: CD155 transfectants
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References:

1. Tahara-Hanaoka S, et al. 2004. Int. Immunol. 16:533.
2. Maier MK, et al. 2007. Eur. J. Immunol.. 37:2214.
3. Bottino C, et al. 2003. J. Exp. Med. 198:557.
4. Dressel R, et al. 2010. FASEB J. 9:134. PubMed

C57BL/6 splenocytes stained with TX56

C57BL/6 splenocytes stained with TX56 APC

C57BL/6 thymocytes stained with TX56

C57BL/6 thymocytes stained with TX56 APC



Description:

Mouse CD155, also known as homolog of polivirus receptor (PVR), is the founding member of a subfamily of immunoglobulin-like adhesion receptors (nectins). Mouse CD155 is expressed on a wide variety of cells of hematopoietic origin apart from its existence on the epithelial cells. The engagement of CD155 with CD226 and CD96 induces cytotoxicity of NK cells and CTL.

Other Names: PVR (poliovirus receptor) homolog
Structure: 70 kd immunoglobulin-like molecule with three Ig-like domains.
Distribution: CD155 is expressed at cell junctions on the primary vascular endothelial cells. Moreover, mouse CD155 is highly expressed on DP thymocytes and expression level is dropped in peripheral single positive CD4+ and CD8+ T cells. CD155 can be detected on T reg, other activated T cells and on NKT cells. Resident monocytes express moderate amount of CD155, but upregulated its expression during inflammation. Other cells, such as IEL, neutrophils and subsets of B cells were found to express CD155 to varying extents.
Function: Apart from its function of adhering junction among contacting epithelial cells, the interaction of DNAM-1 (CD226) with its ligands CD155 and CD112 (nectin 2) induces cytotoxcity of NK cells and CD8+ T cells and cytokine secretion.
Ligand Receptor: CD226 (DNAM-1), CD96
Antigen References:

1. Mendelsohn C, et al. 1989. Cell 56:855.