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Safety Data Sheet (SDS) PE Anti-mouse CD160 Antibody     Product Data Sheet (PDF)    
PE Anti-mouse CD160 Antibody
1315015 25 µg $70.00       
1315020 100 µg $190.00       
Clone: 7H1
Isotype: Rat IgG2a, κ
Reactivity: Mouse
Immunogen: Soluble His-Tag mouse CD160
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume.  It is recommended that the reagent be titrated for optimal performance for each application.

Application References:

1. Tsujimura K, et al. 2006. Immunol. Lett. 106:48. (FC)

C57BL/6 mouse splenocytes were stained

C57BL/6 mouse splenocytes were stained with NK1.1 APC and CD160 (clone 7H1) PE (top) or rat IgG2a, κ PE isotype control (bottom).





Description:

CD160, also known as BY55, is a 27 kD glycoprotein and member of the Ig superfamily. It is anchored to the cell membrane through glycosylphosphatidylinositol (GPI) and forms disulfide-linked multimers. A soluble form of CD160 is secreted by activated CD8+ T cells. Expressed by NK, NKT, γ/δ T cells, intestinal intraepithelial T cells and a subset of memory CD8+ T cells, CD160 binds both classical and non-classical MHC class I molecules. It is also a ligand for HVEM. CD160 enhances proliferation of activated CD8+ T cells and triggers cell cytotoxicity in NK cells.

Other Names: BY55, NK1, NK28
Structure: Membrane glycoprotein, member of the Ig superfamily, 27 kD, glycosylphosphatidylinositol (GPI)-anchored, forms disulfide-linked multimers on the cell surface
Distribution: NK, NKT, γ/δT cells, intestinal intraepithelial T cells, subset of memory CD8+ T cells
Function: Enhances proliferation of activated CD8+ T cells, triggers cell cytotoxicity in NK cells
Ligand Receptor: Classical and non-classical MHC-class I molecules, HVEM
Antigen References:

1. Shui JW, et al. 2011. J. Leukoc. Biol. 89:517.
2. Del Rio ML, et al. 2010. J. Leukoc. Biol. 87:223.
3. Cai G and Freeman GJ. 2009. Immunol. Rev. 229:244.