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Safety Data Sheet (SDS) Purified Anti-mouse CD371 CLEC12A Antibody     Product Data Sheet (PDF)    
Purified Anti-mouse CD371 (CLEC12A) Antibody
1317010 100 µg $180.00       
Clone: 5D3/CLEC12A
Isotype: Rat IgG2a, κ
Reactivity: Mouse
Immunogen: CHO expressing mouse CLEC12A
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application:

FC - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.



Description:

CD371 (CLEC12A), also known as DCAL-2, MICL or CLL-1, is a 30 kD type II transmembrane protein with extracellular C-type lectin domains, belonging to the C-type lectin family.  Its cytoplasmic ITIM motif modulates signaling cascades and is involved in phosphorylation of tyrosine residues in MAP kinases. Mouse CLEC12A is expressed on CD8+ dendritic cells (DCs), a proportion of CD8- dendritc cells, plasmacytoid DCs, monoctyes, macrophages, granulocytes, and B cells.

Other Names: CLL1, MICL, CLL-1, DCAL-2, C-type lectin domain family 12 member A, CD371
Structure: Type II C-type lectin family member, 265 aa, 30.7 kD
Distribution: CD8+ dendritic cells (DCs), a proportion of CD8- dendritic cells, plasmacytoid DCs, monocytes, macrophages, granulocytes, B cells
Function: Negative regulator of granuocyte and monocyte function
Interaction: PTPN6 and PTPN11
Antigen References:

1. Lahoud MH, et al. 2009. J. Immunol. 182:7587.
2. Chen CH, et al. 2006. Blood 107:1459.
3. Marshall AS, et al. 2004. J. Biol. Chem. 279:14792.