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Safety Data Sheet (SDS) PE Anti-mouse CD39 Antibody     Product Data Sheet (PDF)    
PE Anti-mouse CD39 Antibody
1319015 25 µg $105.00       
1319020 100 µg $225.00       
Clone: Duha59
Isotype: Rat IgG2a, κ
Reactivity: Mouse
Immunogen: CD39 cDNA expression vector
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume.  It is recommended that the reagent be titrated for optimal performance for each application.

C57BL/6 mouse lymph node cells

C57BL/6 mouse lymph node cells were stained with CD4 PerCP, CD25 APC, and CD39 (clone Duha59) PE (top) or rat IgG2a, κ PE isotype control (bottom). The data was analyzed by gating on CD4+ cells.





Description:

CD39, nucleoside triphosphate diphosphohydrolase-1 (NTPDase 1), is an ectoenzyme that degrades ATP to AMP. It is a member of the ectonucleoside triphosphate dihydrolases (E-NTPDases), which are involved in regulation of extracellular nucleotide catabolism and controlling the extracellular nucleoside triphosphate pool (NTP). CD39 is the dominant member of this family in the immune system, and is involved in suppression of inflammation and control of platelet activation. CD39 is expressed on B cells, dendritic cells, and a subset of T cells, including regulatory T cells and memory T cells. The coordinated expression of CD39/CD73 on Tregs and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops.

Other Names: Entpd1, NTPDase1
Structure: A member of ectonucleoside triphosphate dihydrolases (E-NTPDases), an ectoenzyme that degrades ATP to AMP
Distribution: B cells, dendritic cells, and a subset of T cells
Function: Involved in suppression of inflammation and control of platelet activation; coordinated expression of CD39/CD73 on Tregs and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops
Interaction: Proteolysis of amyloid precursor protein (APP)
Antigen References:

1. Borsellino G, et al. 2007. Blood 110:1225.
2. Deaglio S, et al. 2007. J. Exp. Med. 204:1257.
3. Bynoe MS, et al. 2008. Trends Immunol. 29:99.
4. Ndhlovu LC, et al. 2010. Eur. J. Immunol. 40:134.