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Safety Data Sheet (SDS) PE Anti-mouse CD193 CCR3 Antibody     Product Data Sheet (PDF)    
PE Anti-mouse CD193 (CCR3) Antibody
1322525 25 µg $135.00       
1322530 100 µg $270.00       
Clone: J073E5
Isotype: Rat IgG2a, κ
Reactivity: Mouse
Immunogen: Mouse CCR3-transfectants
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume.  It is recommended that the reagent be titrated for optimal performance for each application.

C57BL/6 mouse peripheral blood myeloid

C57BL/6 mouse peripheral blood myeloid cells were stained with Gr-1 APC and CD193 (clone J073E5) PE (top) or rat IgG2a, κ PE isotype control (bottom).





Description:

CD193, also known as CC-chemokine receptor 3 (CCR3), CC CKR3, MIP1-α receptor like-2, and eotaxin receptor, is a member of the G protein-coupled, seven transmembrane receptor family. It binds to the CC chemokines eotaxin, eotaxin-2, and eotaxin-3 with high affinity. CD193 has also been reported to bind RANTES, MCP-3, and MCP-4 with low affinity. CD193 is expressed on mouse eosinophils, basophils, mast cells, mononuclear phagocytes, platelets, hematopoietic progenitor cells, and keratinocytes. It is thought to play a role in allergic diseases such as bronchial asthma and allergic rhinitis. CD193 also function as a co-receptor for HIV-1 and HIV-2, and the binding of eotaxin with CD193 has been shown to inhibit HIV infection in some cell types.

Other Names: CC CKR3, MIP1-α receptor like-2, eotaxin receptor, MIP1-alpha receptor like-2
Structure: G-protein coupled, seven transmembrane domain receptor, 356 amino acids
Distribution: Eosinophils, basophils, mast, mononuclear phagocytes, platelets, hematopoietic progenitor, keratinocytes
Function: Co-receptor for HIV-1 and HIV-2, allergy
Ligand Receptor: Eotaxin, eotaxin-2, eotaxin-3, RANTES, MCP-3, and MCP-4
Antigen References:

1. Zlotnik A, et al. 2006. Genome Biol. 7:243.
2. Kodali RB, et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24:1211.
3. Das AM, et al. 2006. J. Pharmacol. Exp. Ther. 318:411.
4. Huaux F, et al. 2005. Am. J. Pathol. 167:1485.
5. Puxeddu I, et al. 2006. J. Allergy Clin. Immunol. 117:103.