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Safety Data Sheet (SDS) Purified Anti-mouse CD37 Antibody     Product Data Sheet (PDF)    
Purified Anti-mouse CD37 Antibody
1331010 100 µg $155.00       
Clone: Duno85
Isotype: Rat IgG2a, κ
Reactivity: Mouse
Immunogen: Expression vector containing full length mouse CD37 gene
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application:

FC - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

C57BL/6 mouse splenocytes were stained

C57BL/6 mouse splenocytes were stained with purified CD37 (clone Duno85, filled histogram) or purified rat IgG2b, κ isotype control (open histogram), followed by anti-rat IgG FITC.



Description:

CD37, also known as Tspan26 is a 40-60 kD member of the tetraspanin (TM4SF) family, with two extracellular regions and both termini in the cytoplasm. CD37 is highly expressed on mature B cells and is also expressed on T cells, monocytes, macrophages, and neutrophils, and dendritic cells to a lesser extent. CD37 forms complexes in the cell membrane with CD53, CD81, CD82, MHC class II and dectin 1. CD37 is essential for B cell survival, regulates T cell proliferation, IgA production, and is involved in dendritic cell migration. CD37 has been described as a promising target in the treatment of B cell malignancies.

Other Names: Tspan26, Tetraspanin-26
Structure: Member of the tetraspanin (TM4SF) family, with two extracellular regions, both termini are cytoplasmic, 40-60 kD
Distribution: Highly expressed on B cells, low expression on T cells, monocytes, macrophages, neutrophils, and dendritic cells
Function: Essential for B cell survival, regulates T cell proliferation, regulates IgA production, involved in dendritic cell migration
Antigen References:

1. Gartlan KH, et al. 2013. Eur. J. Immunol. 43:1208.
2. Annemiek B, et al. 2012. Sci. Signal. 5:82.
3. van Spriel AB. 2011. Biochem. Soc. Trans. 39:512.
4. Heider, KH, et al. 2012. Blood 118:4159.