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Safety Data Sheet (SDS) Purified Anti-mouse IL-17RB Antibody     Product Data Sheet (PDF)    
Purified Anti-mouse IL-17RB Antibody
1331510 100 µg $220.00       
Clone: 9B10
Isotype: Rat IgG2a, κ
Reactivity: Mouse
Immunogen: Recombinant mouse IL-17RB - Fc chimera (human IgG1)
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application:

FC - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Mouse IL-17RB transfected 300.19 cells

Mouse IL-17RB transfected 300.19 cells were stained with purified IL-17RB (clone 9B10, filled histogram) or rat IgG2a, κ (open histogram), followed by anti-rat IgG PE.



Description:

IL-17RB, also known as IL17RH1, belongs to the cytokine receptor family.  IL-17RB possesses a unique intracellular signaling molecule called SEFIR, and is expressed similarily to fibroblast growth factor genes and IL-17R.  It is reported to be expressed on iNKT cells, innate lymphoid cells (ILC), and Th2 cells.  It binds IL-17B and IL-17E (IL-25) but not IL-17A or C.  Its interaction with IL-25 has a higher affinity than that with IL-17B.  Binding of IL-17RB and IL-25/IL-17E induces NF-kB mediated IL-8 production through interaction with TRAF6 and Act1.  IL-17RB has been reported to play a role in autoimmune diseases such as rheumatoid arthritis and asthma.

Other Names: Evi27, IL-17ER, IL17RH1, IL17br, IL-17 receptor B
Structure: Single pass type I transmembrane protein, 55.9 kD
Distribution: iNKT cells, innate lymphoid cells, Th2 cells
Function: Binds IL-25 with higher affinity than IL-17B, can block IL-25 mediated pathology
Ligand Receptor: IL-25/IL-17E
Interaction: TRAF6 and Act1
Antigen References:

1. Hwang SY, et al. 2004. Arthritis Res. Ther. 6:R120.
2. Rickel EA, et al. 2008. J. Immunol. 181:4299.
3. Terashima A, et al. 2008. J. Exp. Med. 205:2727.