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Safety Data Sheet (SDS) Alexa Fluor 647 Anti-mouse IL-17RB Antibody     Product Data Sheet (PDF)    
Alexa Fluor® 647 Anti-mouse IL-17RB Antibody
1331515 25 µg $130.00       
1331520 100 µg $310.00       
Clone: 9B10
Isotype: Rat IgG2a, κ
Reactivity: Mouse
Immunogen: Recombinant mouse IL-17RB - Fc chimera (human IgG1)
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.

Mouse IL-17RB transfected 300.19 cells

Mouse IL-17RB transfected 300.19 cells were stained with IL-17RB (clone 9B10) Alexa Fluor® 647 (filled histogram) or rat IgG2a, κ Alexa Fluor® 647 (open histogram).



Description:

IL-17RB, also known as IL17RH1, belongs to the cytokine receptor family.  IL-17RB possesses a unique intracellular signaling molecule called SEFIR, and is expressed similarily to fibroblast growth factor genes and IL-17R.  It is reported to be expressed on iNKT cells, innate lymphoid cells (ILC), and Th2 cells.  It binds IL-17B and IL-17E (IL-25) but not IL-17A or C.  Its interaction with IL-25 has a higher affinity than that with IL-17B.  Binding of IL-17RB and IL-25/IL-17E induces NF-kB mediated IL-8 production through interaction with TRAF6 and Act1.  IL-17RB has been reported to play a role in autoimmune diseases such as rheumatoid arthritis and asthma.

Other Names: Evi27, IL-17ER, IL17RH1, IL17br, IL-17 receptor B
Structure: Single pass type I transmembrane protein, 55.9 kD
Distribution: iNKT cells, innate lymphoid cells, Th2 cells
Function: Binds IL-25 with higher affinity than IL-17B, can block IL-25 mediated pathology
Ligand Receptor: IL-25/IL-17E
Interaction: TRAF6 and Act1
Antigen References:

1. Hwang SY, et al. 2004. Arthritis Res. Ther. 6:R120.
2. Rickel EA, et al. 2008. J. Immunol. 181:4299.
3. Terashima A, et al. 2008. J. Exp. Med. 205:2727.


This product is provided under an agreement between Life Technologies Corporation and Sony Biotechnology Inc. and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications, and corresponding non-U.S. equivalents, owned by and/or licensed to Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product in research and/or development conducted by the buyer (whether the buyer is an academic or for profit entity). The buyer cannot sell or otherwise transfer (a) this product (b) its components or (c) materials made using this product or its components to a third party or otherwise use this product or its components or materials made using this product or its components for Commercial Purposes. Commercial Purposes means any activity by a party for consideration and may include, but is not limited to (1) use of the product or its components in manufacturing, (2) use of the product or its components for therapeutic, diagnostic or prophylactic purposes, or (3) resale of the product or its components, whether or not such product or its components are resold for use in research. For information on purchasing a license to this product for any other use, contact Life Technologies Corporation, Molecular Probes Detection Technologies, Attn: Business Development, 29851 Willow Creek Road, Eugene, OR 97402, USA, Tel: (541) 465-8300. Fax: (541) 335-0504.