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Safety Data Sheet (SDS) PerCP/Cy55 Anti-mouse CD160 Antibody     Product Data Sheet (PDF)    
PerCP/Cy5.5 Anti-mouse CD160 Antibody
1315035 25 µg $105.00       
1315040 100 µg $235.00       
Clone: 7H1
Isotype: Rat IgG2a, κ
Reactivity: Mouse
Immunogen: Soluble His-Tag mouse CD160
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with PerCP/Cy5.5 under optimal conditions. The solution is free of unconjugated PerCP/Cy5.5 and unconjugated antibody.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

* PerCP/Cy5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.

Application References:

1. Tsujimura K, et al. 2006. Immunol. Lett. 106:48. (FC)

C57BL/6 mouse splenocytes were stained

C57BL/6 mouse splenocytes were stained with NK1.1 APC and CD160 (clone 7H1) PerCP/Cy5.5 (top) or rat IgG2a, κ PerCP/Cy5.5 isotype control (bottom).





Description:

CD160, also known as BY55, is a 27 kD glycoprotein and member of the Ig superfamily. It is anchored to the cell membrane through glycosylphosphatidylinositol (GPI) and forms disulfide-linked multimers. A soluble form of CD160 is secreted by activated CD8+ T cells. Expressed by NK, NKT, γ/δ T cells, intestinal intraepithelial T cells and a subset of memory CD8+ T cells, CD160 binds both classical and non-classical MHC class I molecules. It is also a ligand for HVEM. CD160 enhances proliferation of activated CD8+ T cells and triggers cell cytotoxicity in NK cells.

Other Names: BY55, NK1, NK28
Structure: Membrane glycoprotein, member of the Ig superfamily, 27 kD, glycosylphosphatidylinositol (GPI)-anchored, forms disulfide-linked multimers on the cell surface
Distribution: NK, NKT, γ/δT cells, intestinal intraepithelial T cells, subset of memory CD8+ T cells
Function: Enhances proliferation of activated CD8+ T cells, triggers cell cytotoxicity in NK cells
Ligand Receptor: Classical and non-classical MHC-class I molecules, HVEM
Antigen References:

1. Shui JW, et al. 2011. J. Leukoc. Biol. 89:517.
2. Del Rio ML, et al. 2010. J. Leukoc. Biol. 87:223.
3. Cai G and Freeman GJ. 2009. Immunol. Rev. 229:244.


This product or portions thereof is manufactured under license from GE Healthcare under U.S. Patent Numbers 5,268,486; 5,569,587; 5,627,027 and patents or pending applications that are continuations, continuations-in-part, re-examinations, divisionals, reissues or foreign equivalents thereof. THIS MATERIAL IS SUBJECT TO PROPRIETARY RIGHTS OF GE HEALTHCARE BIO-SCIENCES CORP. AND CARNEGIE MELLON UNIVERSITY AND MADE AND SOLD UNDER LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. THIS PRODUCT IS LICENSED FOR SALE ONLY FOR RESEARCH. IT IS NOT LICENSED FOR ANY OTHER USE. THERE IS NO IMPLIED LICENSE HEREUNDER FOR ANY COMMERCIAL USE.
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