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Safety Data Sheet (SDS) APC Anti-human CD130 Gp130 Antibody     Product Data Sheet (PDF)    
APC Anti-human CD130 (gp130) Antibody
2410025 25 tests $120.00       
2410030 100 tests $280.00       
Clone: 2E1B02
Isotype: Mouse IgG2a, κ
Reactivity: Human
Immunogen: GP130 (23-619aa) recombinant protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Concentration: Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application:

FC - Quality tested

Recommended Usage:

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells or 5 µl per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Human peripheral blood lymphocytes were

Human peripheral blood lymphocytes were stained with CD130 (clone 2E1B02) APC (filled histogram) or mouse IgG2a, κ APC isotype control (open histogram).



Description:

CD130, also known as gp130 (glycoprotein 130), IL6ST (IL-6-receptor-associated signal transducer), or common β chain, is a member of the hemotopietic cytokine receptor family. CD130 is a common subunit associated with the receptors for several cytokines, such as IL-6, IL-11, Oncostatin M (OSM), CNTF (ciliary neurotrophic factor), CT-1, Neuropoietin (NP), and IL-27. CD130 participates in the JAK-STAT signaling pathway and is expressed on T cells, activated B cells, monocytes, plasma cells, and endothelial or epithelial cells.

Other Names: GP130, GP-130, IL6ST, IL-6Rβ, Oncostatin M Receptor
Structure: 130 kD type I transmembrane glycoprotein.
Distribution: T cells, activated B cells, monocytes, plasma cells, endothelial cells and epithelial cells.
Function: Common β subunit of IL-6 receptor family, plays a role in signal transduction.
Ligand Receptor: IL-6, IL-11, OSM, CNTF, CT-1, NP, IL-27.
Antigen References:

1. Arzt E, et al. 2001. J. Clin. Invest. 108:1729.
2. Bravo J, et al. 2000. EMBO J. 19:2399.
3. Wang XJ, et al. 1998. Blood 91:3308.
4. Hibi. M, et al. 1990. Cell. 63:1149.
5. Schlossman S, et al. 1995. ed. Leukocyte Typing V. New York. Oxford University Press.